Bea’s work published in Immunity

Congratulations to Beatrice Zitti, whose postdoc work Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a is now published in Immunity! This work was the result of a long-standing collaboration between the Bryceson group and Liv Eidsmo’s team at Karolinska and in Copenhagen.

The study uncovers how tissue-resident memory T cells can differentiate into highly cytotoxic cells in the skin, finding a role for RUNX2 and RUNX3, and further evaluates transcription factor regulation of these cells in a melanoma disease setting.